One and the same inter-organizational business process - such as e-procurement - may be executed differently in different industries, geopolitical regions, etc. Thus, a standardized reference model for inter-organizational business process must be customized to the specific business context (industry, region, etc.). In order to share, search, and (partially) re-use context specific adaptations it is essential not only to store the adaptations, but also a business context model where these adaptations are valid. Therefore, we present our ontology based business context model and explain how it can be applied to generic models of semantically interoperable data blocks, so-called Core Components. Core Components are standardized by the United Nations Centre for Trade Facilitation and Electronic Business (UN/CEFACT), and their adaptations are exchanged between business partners in the course of inter-organizational business processes. If we could assign a business context to a business process, we could prevent negative trends in today’s business, such as interoperability issues, inconsistencies and heterogeneous interpretations of the interchanged electronic business documents.